Opzelura Ruxolitinib Cream In Pakistan Opzelura (ruxolitinib) 1.5% is a prescription-strength topical cream and a first-of-its-kind Janus kinase (JAK) inhibitor. It is specifically designed to target the overactive immune signals in the skin that lead to chronic inflammation and pigment lossb How It Works Opzelura works by blocking JAK1 and JAK2 enzymes. In conditions like eczema and vitiligo, the immune system becomes overactive, sending too many signals through the JAK-STAT pathway. For Eczema: It reduces the internal "itch-scratch" cycle by calming inflammation directly at the site For Vitiligo: It inhibits the immune cells that attack melanocytes (pigment-producing cells), allowing the skin to potentially regain its natural color over time Benefits: Promotes repigmentation by reducing inflammation that hinders melanocyte activity. Effective for facial and non-facial vitiligo, particularly in early stages. Provides a non-invasive treatment option. FDA-approved, ensuring clinical efficacy and safety. Usage For topical application only — apply a thin layer to affected areas as directed by your healthcare provider.